Methods and Models for Determining Likelihood of Cancer Drug Treatment Success Utilizing Predictor Biomarkers, and Methods of Diagnosing and Treating Cancer Using the Biomarkers
Leslie TIMPE;Alexandra PIRYATINSKA;Bruce MACHER;Ten-Yang YEN
发明人:
Bruce MACHER,Leslie TIMPE,Ten-Yang YEN,Alexandra PIRYATINSKA
申请号：
US14558618
公开号：
US20150254433A1
申请日:
2014.12.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A method of identifying one or more biomarkers associated with one or more drugs effective to stop or repress proliferation of cancer cells, and a system for predicting effectiveness of the same. The method includes statistically analyzing (i) a first dataset of expression levels of proteins or glycoproteins in the cancer cells and (ii) a second dataset of responses of the cancer cells to drugs to identify at least one biomarker associated with effective repression of the cancer cells, and correlating or associating at least one protein or glycoprotein biomarker with a response of the cells to at least one of the drugs effective to stop or repress the proliferation of the cancer cells. The protein and/or glycoprotein expression level datasets may be generated experimentally or taken from published information. The method advantageously determines and/or predicts drug sensitivity of various cancer cells using protein and glycoprotein biomarkers.
