Kevin M. Klucher;Katherine E. Henderson;Pallavur V. Sivakumar;Wayne R. Kindsvogel
发明人:
Kevin M. Klucher,Wayne R. Kindsvogel,Pallavur V. Sivakumar,Katherine E. Henderson
申请号：
US13606176
公开号：
US20130022571A1
申请日:
2012.09.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
