Kevin M. Klucher;Katherine E Henderson;Pallavur V Sivakumar;Wayne R Kindsvogel
发明人:
Kevin M. Klucher,Pallavur V Sivakumar,Wayne R Kindsvogel,Katherine E Henderson
申请号:
US13225741
公开号:
US08318147B2
申请日:
2011.09.06
申请国别(地区):
US
年份:
2012
代理人:
摘要:
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.