One drug filled synthetic resin ampoule 1 has the self-supporting ampoule body 7 and a drug 6 mounted in ampoule body 7. Ampoule body 7 has a superposed distal part 3 and works as self-supporting, and the hollow parts 71 with a drug housing part 78, a breakable part 5 provides between the lower part of distal part 3 and the top of hollow parts 71. Distal part 3 has pressing parts 31,32, guides pressure in predetermined direction during the breaking operation of breakable part 5. Hollow parts 71 have the bottom surface portions 9 for self-supporting. Bottom surface portions 9 have widening parts 41,42, extend in predetermined direction (direction X, direction Y), wherein biasing member 31,32 are guided during breaking operation.