Extract of Grindelia, which is polar, is claimed. Independent claims are included for: (1) a cosmetic or dermatological composition comprising the extract; and (2) a preparation of the extract comprising contacting the aerial part of Grindeliaflower with a polar solvent; optionally heating; optionally agitating; optionally cooling; filtering the mixture to obtain the filtrate, which is the polar extract of Grindelia; and optionally stabilizing or drying of the obtained filtrate. ACTIVITY : Dermatological. MECHANISM OF ACTION : Metallo protease inhibitor.