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PROCÉDÉ DE CONJUGAISON AMÉLIORÉ ET NOUVEAUX CONJUGUÉS OLIGOSACCHARIDE SYNTHÉTIQUE-PROTÉINE OBTENUS À L'AIDE DE CELUI-CI
专利权人:
Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd.
发明人:
申请号:
EP15849268.6
公开号:
EP3204396A4
申请日:
2015.10.08
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours. The said oligosaccharide-protein conjugates are useful in production of monovalent vaccine or multivalent combination vaccines and as diagnostic tool.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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