THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;PETER MACCALLUM CANCER CENTRE
发明人:
PATERSON, Yvonne,NEESON, Paul,DARCY, Phil
申请号:
USUS2016/016455
公开号:
WO2016/126878A9
申请日:
2016.02.03
申请国别(地区):
US
年份:
2016
代理人:
摘要:
This disclosure provides methods and compositions for using Listeria monocytogenes expressing truncated listeriolysin O (LLO) as an adjuvant for conditioning the tumor microenvironment prior to additional administration of an immunotherapy to a subject. In some instances, the subject is receiving cell based therapy. In other instances the subject is receiving a T cell engraftment.