a- Mock -o- CAR caTCR-1 CSR-1 § 2 9 450 - 6 >； E E g 300- )- 11, 2 150- 0- 10 15 20 25 30 35 Days post T cell dosing 600 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT omit IIl °nolo Em mil ono oimIE (10) International Publication Number WO 2018/200583 Al (51) International Patent Classification: A61K 35/17 (2015.01) CO7K 16/30 (2006.01) A61P 35/00 (2006.01) CO7K 19/00 (2006.01) C07K 14/725 (2006.01) C12N 5/0783 (2010.01) (21) International Application Number: PCT/US2018/029218 (22) International Filing Date: 24 April 2018 (24.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/490,576 26 April 2017 (26.04.2017) US 62/490,578 26 April 2017 (26.04.2017) US 62/490,580 26 April 2017 (26.04.2017) US (71) Applicant: EUREKA THERAPEUTICS, INC. [US/US]； 5858 Horton Street, Suite 370, Emeryville, California 94608 (US). (72) Inventors: LIU, Hong； 5573 Woodview Drive, El So- brante, California 94803 (US). ZHANG, Pengbo； 4659 Rousillon Avenue, Fremont, California 94555 (US). HO- RAN, Lucas； 2340 Powell Street, #156, Emeryville, Cal- ifornia 94608 (US). XU, Yiyang； 7652 Chestnut Way, Pleasanton, California 94588 (US). STALEY, Binnaz K.； 2408 San Carlos Avenue, San Carlos, California 94070 (US). LIU, Lianxing； 1385 20th Avenue, Apt. 2, San Fran- cisco, California 94122 (US). YUN, Hongruo； 481 Faxon Avenue, San Francisco, California 94112 (US). (74) Agent: QI, Yan； Morrison & Foerster LLP, 755 Page Mill Road, Palo Alto, California 94304-1018 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG
