The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of PAR4, in particular, by targeting natural antisense polynucleotides of PAR4. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PAR4.Cette invention concerne des oligonucléotides antisens qui modulent lexpression et/ou la fonction de PAR4, en particulier en ciblant les polynucléotides antisens naturels de PAR4. Linvention concerne également lidentification de ces oligonucléotides antisens et leur utilisation dans le traitement des maladies et des affections associées à lexpression de PAR4.