Fundación Centro Nacional de Investigaciones Oncológicas Carlos III
发明人:
申请号：
EP16382147.3
公开号：
EP3228701A1
申请日:
2016.04.05
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention relates to an ex vivo method for preparing lymphocytes capable of infiltrating a solid tumor in a human subject, comprising: (a) administering CD45+ cells from said subject to an immunodeficient non-human organism, wherein the non-human organism contains a xenograft of the solid tumor generated by implanting cells or tissue from the tumor into the non-human organism； (b) maintaining the non-human organism for sufficient time for the CD45+ cells to infiltrate the tumor xenograft； and (c) recovering lymphocytes from the xenograft. The invention further relates to a cellular population of lymphocytes obtainable by said method and uses thereof.
