SAKAMURI, SUKUMAR,BRADSHAW, CURT W.,ELTEPU, LAXMAN,MEADE, BRYAN R.,LAM, SON
申请号：
CA3033867
公开号：
CA3033867A1
申请日:
2017.08.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical^ enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.
