Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition. The present invention is directed to casted constructs for treating, reconstructing or replacing damaged or diseased biological tissue. In a preferred embodiment, the casted constructs comprise an ECM member having a biomaterial composition disposed within the vasculature of the ECM member. In some embodiments of the invention, the casted constructs comprise a seamless ECM material derived from a mammalian tissue source. According to the invention, the seamless ECM material can be derived from various mammalian tissue sources, including, without limitation, small intestine, large intestine and umbilical cord.
