SACCHARIDES CAPSULAIRES MENINGOCOCCIQUES HYPO ET HYPERACETYLES

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专利权人:

CHIRON SRL

发明人:

COSTANTINO, PAOLO,BERTI, FRANCESCO

申请号：

CA2541020

公开号：

CA2541020C

申请日:

2004.10.04

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Capsular saccharides derived from serogroups W135 and Y of Neisseriameningitidis have altered levels of O-acetylation at the 7 and 9 positions oftheir sialic acid residues, and can be used to make immunogenic compositions.Relative to unmodifed native saccharides, derivatives of the invention arepreferentially selected during conjugation to carrier proteins, and conjugatesof the derivatives show improved immunogenicity compared to nativepolysaccharides.

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