가톨릭대학교 산학협력단;CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人:
이문용,차정호,신유진,LEE, MUN YONG,CHA, JUNG HO,SHIN, YOO JIN
申请号：
KR1020120041597
公开号：
KR1020120120074A
申请日:
2012.04.20
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A composition for a bio marker for determining neuronal cell debris using osteopontin is provided to remove neuronal cell debris and degenerating neurite. CONSTITUTION: A composition for a bio marker for determining neuronal cell apoptosis contains osteopontin for providing information for diagnosing nervous system diseases. The neuronal cells are CA1(cornu ammonis 1) or striatum of hippocampus. The nervous system diseases are ischemic brain injury, traumatic neural injury, stroke, CNS or PANA demyelination diseases, neuropathy, or neurodegenerative diseases. The composition is used for removing debris caused by neuronal cell apoptosis and degenerating neurite. A composition for treating nervous system diseases contains the osteopontin. The composition also contains cells transformed with a recombinant expression vector or a vector containing osteopontin gene.본 발명은 오스테오폰틴(osteopontin)의 발현이 신경세포의 사멸에 대한 지표인 사실 및 오스테오폰틴이 신경세포사에 의한 신경세포 데브리스(debris) 및 퇴행중 신경돌기를 타겟팅하여 이들을 제거하는데 사용되는 사실과 이의 구체적인 작용기작에 기초하는, 오스테오폰틴의 신규한 용도에 관한 것이다.
