GLAXOSMITHKLINE BIOLOGICALS S.A.;THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
发明人:
FOSTER, TIMOTHY,HIGGINS, JUDY,JOSEFSSON, ELISABET,GEOGHEGAN, JOAN,DEQUESNE, GUY,TARKOWSKI, ANDREJ (DECEASED)
申请号：
CA2768485
公开号：
CA2768485C
申请日:
2010.07.16
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
