MURAI, Norio,KEANEY, Gregg F.,KANADA SONOBE, Regina,NAGAO, Satoshi,KOTAKE, Yoshihiko,GEARHART, Nicholas C.,PRAJAPATI, Sudeep,TIVITMAHAISOON, Parcharee,KIRA, Kazunobu,ZHENG, Guo Zhu,LIU, Xiang,ARAI, Ke
申请号：
PE2016002233
公开号：
PE20170384A1
申请日:
2015.05.13
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to pyridine derivatives selected from Formula 1, 2, 3 or 4. They also include ingredients that contain these compounds. These compounds can be used to treat cancer, such as invertebrates, leukaemia or single tumors. These compounds are: 4-cyclohexane-1-carbohydrate (2S, 3S, 6S, 7R, 10R, e) - 7, 10-dihydroxi-3, 7-dimethyl-12-oxo-2 - ((R, 2e, 4e) - 6 - (piridin-2-il) hepta-2, 4-dien-2-il) oxachlordodec-4-en-6-il (compound 1)；4-methylpyridine-1-carboxilato de (2S, 3S, 6S, 7R, 10R, e) - 7, 10-dihydroxi-3, 7-dimethyl-12-oxo-2 - ((R, 2e, 4e) - 6 - (piridin-2-il) hepta-2, 4-dien-2-il) oxacilodec-4-en-6-ilo (compila 2)；4 - (azerbaijan-1-il) piperidine-1-carboxilato de (2S, 3S, 6S, 7R, 10R, e) - 7, 10-dihydroxi-3, 7-dimethyl-12-oxy-2 - ((R, 2e, 4e) - 6 - (piridin-2-il) hepta-2, 4-dien-2-il) oxiclodec-4-en-6-ilo (compound 3)；Y[1，4'-bipiperidine]-1'-carboxilato de（2S，3S，6S，7R，10R，e）-7，10-dihydroxi-3，7-dimethy-12-oxo-2-（（R，2E，4E）-6-（Piridin-2，4-dien-2-il）hepta-2-il）oxaciclododec-4-en-6-iol（compiles 4）Se refiere a derivados piridinicos de pladienolida seleccionados de la formula 1, 2, 3 o 4. Tambien comprenden composiciones que contienen dichos compuestos. Estos compuestos pueden ser utiles en el tratamiento del cancer como sindrome mielodisplasico, leucemia o tumores solidos. Estos compuestos son: 4-cicloheptilpiperazina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-il (Compuesto 1)； 4-metilpiperazina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-ilo (Compuesto 2)； 4-(azepan-1-il)piperidina-1-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-dien-2-il)oxaciclododec-4-en-6-ilo (Compuesto 3)； y [1,4’-bipiperidina]-1’-carboxilato de (2S,3S,6S,7R,10R,E)-7,10-dihidroxi-3,7-dimetil-12-oxo-2-((R,2E,4E)-6-(piridin-2-il)hepta-2,4-d
