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Antibacterial compounds 1,2 Dihydro 3h pyrrolo [1,2-c] - 3-one replaced imidazole
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
申请号:
ARP160102671
公开号:
AR105889A1
申请日:
2016.09.01
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
This application relates to antimicrobial compounds, in particular aerobic and anaerobic negative Gram-negative bacteria. 1. Claim 1: a compound of formula (1), wherein m is a group of formula (2),(3) And (4),Methyl (3) methyl fluoro (3) Tri (3-fluoro (3) methyl fluoro (3) methyl fluoro (3) methyl fluoro (3) Tri (1-1-1-1-1-1-1.din-1-il) methyl, - 6-1-1-1-1-1-1) methylene (1-3) methylene (1-3) dioxoxy (1-3) di (1-3) Di Di Di (L) carbides; (4-hydroxypyridine-1-il) carbonate,- (1) methyl - (1 - (1) methyl - (1 - (1) methyl - (1) - 1-ilo, 1 - (2 - (dimethylaminomethylmethylmethylmethylamine) 1 - ((3-hydroxyoxyethyl) 1 - (3-hydrofluorocarboxy-1-ilo, 2 - (morphine ethyl) 1 - (1 -) (4-methyldipyridamide zinil) - 1-ilo (4-methyldipyridamide-1-carboxyethyl) 1 - (4-fluorodipyridamide-3-1) methyl, 1 - (3) - (3 ------ (3 ---------- (3 ------------ (3 ------------ (3 ---------- hydrogen carbonate)1 - (4-methylpyridine-1-carbides or N - (methylazeidin-3-il) methyl oxycarbonate, or R 1b represents a group Q, q is a formula group (5),(6) And (7),where XA¹ represents H, methyl-d, methyl-d2, C₁₋₄-alkyl,Acetyl, w-halogenated tar c832283331;w-hydroxyalkyl C₂₋₃,2,3-dihydroxyprop-1-yl, 3-hydroxy-2- (hydroxymethyl) prop-1-yl, oxetane-3-yl, tietan-3-yl, 1,1-dioxidothiethane-3-yl, cycloalkyl C₃₋ ₆,3-hydroxycyclobut-1-yl, tetrahydropyran-4-yl or cycloalkyl C₃₋₆alkyl C₁₋₃,XA²¹ and XA²² each independently represent H, alkyl Cilo,a. Halogenated tar c833218d833123o hydroxi codilo c833218d833123;X3 stands for H, i.e. c832131 asphalt or halogen, provided that XA1 stands for oxetan-3-ilo, with at least one xaa2,XA²² and XA³ do not represent H; XB¹ represents H, C₁₋₄ alkyl,w-hydroxyalkyl C₂₋₃,cycloalkyl C₃₋₆,1. Oxetan-3-ilo or tetrahydropiran-4-ilo, XB2 and XB2 respectively represent h, tar c833218331;a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;E xb83088 means h, halogen, hydroxy or c83218c8331;Xc1 for H, let c832131;cycloalkyl C₃₋₆,w-hydroxyalkyl C₂₋₃,1. Oxetan-3-ilo or tetrahydrop
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