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8 - carbamoyl - 2 - (2 , 3 - disubstituted pyrid - 6 - yl) -1 , 2 , 3 , 4 - tetrahydroisoquinoline derivatives as apoptosis - inducing agents for the treatment of cancer and immune and autoimmune diseases
专利权人:
AbbVie Inc.
发明人:
WANG, Le,DOHERTY, George,WANG, Xilu,TAO, Zhi-Fu,BRUNKO, Milan,KUNZER, Aaron R.,WENDT, Michael D.,SONG, Xiaohong,FREY, Robin,HANSEN, Todd M.,SULLIVAN, Gerard M.,JUDD, Andrew,SOUERS, Andrew
申请号:
AU2017206246
公开号:
AU2017206246A1
申请日:
2017.07.20
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
#$%^&*AU2017206246A120170810.pdf#####8 - CARBAMOYL - 2 - (2, 3 - DISUBSTITUTED PYRID - 6 - YL) -1 , 2 , 3, 4 - TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABSTRACT Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y' is phenylene or heteroarylene; L' is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; ZI is C(O)OR 9, C(O)NR 0R" , C(O)R", NR1 0C(O)R", etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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