WANG, Le,DOHERTY, George,WANG, Xilu,TAO, Zhi-Fu,BRUNKO, Milan,KUNZER, Aaron R.,WENDT, Michael D.,SONG, Xiaohong,FREY, Robin,HANSEN, Todd M.,SULLIVAN, Gerard M.,JUDD, Andrew,SOUERS, Andrew
申请号：
AU2017206246
公开号：
AU2017206246A1
申请日:
2017.07.20
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017206246A120170810.pdf#####8 - CARBAMOYL - 2 - (2, 3 - DISUBSTITUTED PYRID - 6 - YL) -1 , 2 , 3, 4 - TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABSTRACT Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl； Y' is phenylene or heteroarylene； L' is a linker； Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl； ZI is C(O)OR 9, C(O)NR 0R" , C(O)R", NR1 0C(O)R", etc.
