您的位置: 首页 > 农业专利 > 详情页

8-carbamoyl-2- (2,3-di-substituted pyrid-6-yl) -1,2,3,4-tetrahydroisoquinoline derivatives as apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
专利权人:
AbbVie Inc.
发明人:
WANG, Le,DOHERTY, George,WANG, Xilu,TAO, Zhi-Fu,BRUNKO, Milan,KUNZER, Aaron R.,WENDT, Michael D.,SONG, Xiaohong,FREY, Robin,HANSEN, Todd M.,SULLIVAN, Gerard M.,JUDD, Andrew,SOUERS, Andrew
申请号:
DK12780605
公开号:
DK2766361T3
申请日:
2012.10.11
申请国别(地区):
DK
年份:
2016
代理人:
摘要:
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充