COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIBROMODULCITOL
Methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving as monotherapy or reducing side effects in patients undergoing treatment for cancer. Such methods and compositions are applicable to substitute hexitols such as dibromodulcitol or analogs, derivatives, or prodrugs thereof. The use of these compositions in conjunction with radiation or other conventional chemoterapeutic agents or biotherapeutic agents such as antibodies, vaccines, cytokines, lymphokines, gene and antisense therapies, or other chemotherapeutic or biotherapeutic agents, would provide significant improvement of patients undergoing treatment for cancer.La présente invention concerne des procédés et des compositions pour améliorer lefficacité thérapeutique dagents thérapeutiques auparavant limités par une performance thérapeutique suboptimale, soit par amélioration de lefficacité en monothérapie, soit par réduction des effets secondaires. De tels procédés et compositions sont particulièrement applicables aux hexitols substitués comme le dibromodulcitol ou aux analogues, dérivés ou promédicaments de ceux-ci.
