The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R 1 and R 2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.本發明係關於式(I)之1H-喹唑啉-2,4-二酮,其中R1及R2如說明書中之界定,其製備、其作為醫藥品之用途及含有其之醫藥組合物。另外,揭示用於製造式(I)之化合物及包含式(I)化合物之組合的中間物。