THE JOHNS HOPKINS UNIVERSITY;CARDIOXYL PHARMACEUTICALS, INC.
发明人:
JOHN P. TOSCANO,FREDERICK ARTHUR BROOKFIELD,ANDREW D. COHEN,STEPHEN MARTIN COURTNEY,LISA MARIE FROST,VINCENT JACOB KALISH
申请号：
PT12195118
公开号：
PT2586434T
申请日:
2007.03.16
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
