Hector F. DeLuca,Agnieszka Glebocka,Lori A. Plum,Margaret Clagett-Dame,Rafal R. Sicinski
申请号：
US12895540
公开号：
US08217023B2
申请日:
2010.09.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
19-nor-vitamin D analogs having an additional cyclopentene ring connecting carbon 1 and carbon 2, or connecting carbon 3 and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit selective in vitro activities, making them therapeutic agents for the treatment or prophylaxis of some types of cancers, particularly leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
