Ashutosh Chilkoti,Yizhi Qi,Michael S. Hershfield,Nancy J. Ganson
申请号：
US15387540
公开号：
US10392611B2
申请日:
2016.12.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
