SUBSTITUTED 2- (2,6-DIOXOPIPERIDIN-3-YL) -PHTHALIMIDES AND -1-OXOISOINDOLINES AND METHOD FOR REDUCING THE TNF-ALPHA MIRROR

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专利权人:

Celgene Corp.

发明人:

George MULLER,David STIRLING,Roger CHEN

申请号：

DE69717831

公开号：

DE69717831T3

申请日:

1997.07.24

申请国别(地区):

DE

年份:

2018

代理人:

摘要：

Substituted 2-(2,6-dioxopiperidin-3-yl)phtalimides and l-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF alpha in a mammal. Typical embodiments are 1-oxo-2(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.

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