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RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS (RSV) AND VACCINES
专利权人:
发明人:
申请号:
EP14846254.2
公开号:
EP3046578A2
申请日:
2014.09.11
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Described herein is a recombinant respiratory syncytial virus (RSV) having an attenuated phenotype. In one embodiment, recombinant RSV includes an M2-2 protein with a mutation that renders the M2-2 protein inactive or prevents expression of the M2-2 protein. In one embodiment, the amino acid at position 66 in the F subunit has a positively charged side chain. Nucleic acids encoding recombinant RSV are also described, as well as vectors containing the nucleic acids.
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