CHERNOVSKAYA TATYANA VENIAMINOVNA,DENISOV LEV ALEKSANDROVICH,MOROZOV DMITRY VALENTINOVICH,RUDENKO ELENA GEORGIEVNA,KLENOVA ANGELINA VSOVOLODOVNA
申请号：
MX2011007458
公开号：
MX2011007458A
申请日:
2011.07.12
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The invention is related to the pharmaceutical industry and medicine, in particular, to new PEG-interferon derivatives and the discovery of a new functionally active, highly stable conjugate of interferon to polyethylene glycol with an activity of interferon alpha, with reduced immunogenicity, with prolonged biological effects and improved pharmacokinetic parameters of general formula: (I) where: n - integral values from 227 to 10 000, so that the molecular weight of PEG is about 10 000 - 40 000 Da； m - integer >； 4； IFN- natural or recombinant polypeptide having the activity of IFN-alpha. Also, the invention is related to drugs containing the declared conjugate of the formula (I), pharmaceutical compositions containing PEG-IFN conjugate and therapeutically acceptable excipients suitable for treatment of viral infections and cancer, as well as diseases associated with primary or secondary immunodeficiency. The invention is related to the use of conjugate of formula (I) in medicinal products, which have antiviral, antiproliferative and immunomodulatory activity, to approaches for prevention and / or treatment of diseases associated with primary or secondary immunodeficiency that include administration of therapeutically effective amount of conjugate of formula (I), and to the container with such pharmaceutical composition..La invención está relacionada con la industria farmacéutica y la medicina, en particular, con los nuevos derivados de interferón- PEG y al descubrimiento de un nuevo conjugado funcionalmente activo y muy estable de interferón con polietilenglicol con una actividad de interferón alfa, con inmunogenicidad reducida, con efectos biológicos prolongados y parámetros farmacocinéticos, mejorados de fórmula general: (ver fórmula) donde: n - valores enteros de 227 a 10,000, de modo que el peso molecular del PEG es aproximadamente 10,000 a 40,000 Da； m - entero = 4； IFN - polipéptido natural o recombinante que muestra actividad de IFN-alfa. Además, la inv
