FU, ROGER,傅 罗杰,傅 羅傑,ZAMLOOT, MICHAEL S.,山姆鲁 麦克,山姆魯 麥克,YUM, SU IL,亚姆 苏,亞姆 蘇,CHAO, WENDY,乔 温蒂,喬 溫蒂,SU, HUEY-CHING,苏惠清,蘇惠清
申请号：
TW103109572
公开号：
TW201521723A
申请日:
2014.03.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present disclosure provides extended release compositions, including formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.本發明提供延長釋放組合物,包括包含所述組合物之調配物,其呈現活性劑之理想溶解同時保持其在劑型中之物理穩定性,包括例如提供降低之樣品可變性,例如呈降低之膠囊間可變性及/或活性劑自組合物之平均釋放之儲存時間依賴性變化降低之形式。亦提供製備及投與所揭示之組合物及調配物的相關方法。
