The present invention provides composition and preparation includes luteinising hormone-releasing hormo (LHRH) or lhrh simulations With the analog of curcumin or curcumin. LHRH or lhrh simulations can be fused or be bound to the analog of curcumin or curcumin. The present invention combines and preparation can also include the drug of anti-proliferate. Inventive composition and preparation can be used for inhibiting intracellular Treat excess proliferative disease With treatment tumor formation, tumour, cancer or pernicious.