The invention provides combinations and formulations including a luteinizing hormone-releasing hormone (LHRH) or a LHRH analog and curcumin or a curcumin analog. LHRH or LHRH analog can be fused or conjugated to a curcumin or curcumin analog. Invention combinations and formulations can also include an anti-cell proliferative drug. Invention combinations and formulations can be used for inhibiting proliferation of a cell treating a hyperproliferative disorder and treating a neoplasia, tumor, cancer or malignancy.