System and method for automatic radiography imaging parameter generation by use of extant patient information. The patient information is categorized, and one or more radiography imaging parameters of a radiographic device are selected and processed according to a knowledge-based model applied to a selection of at least one patient information category. A value for the selected imaging parameter(s) is output. Values for several imaging parameters may be automatically generated according to the processing and optimization. Alternatively, a value, or a range of values, may be suggested for presentation to a clinician. The processing and optimization of the radiography imaging parameters may be based on a subset of the patient information.
