LIU YONG-JUN,VOO KUI SHIN,BOVER LAURA,TSURUSHITA NAOYA,KUMAR SHANKAR,TSO J. YUN
申请号：
CL2016003052
公开号：
CL2016003052A1
申请日:
2016.11.28
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.MÉTODO IN VITRO PARA DETECTAR LA PRESENCIA DE CÉLULAS T OX40 POSITIVAS EN UNA MUESTRA BIOLÓGICA QUE COMPRENDE LA UTILIZACIÓN DE ANTICUERPOS ANTI OX40 DIVISIONAL SOLICITUD 201502526
