LIU, YONG-JUN,VOO, KUI SHIN,BOVER, LAURA,TSURUSHITA, NAOYA,TSO, J., YUN,KUMAR, SHANKAR
申请号：
CL2013000545
公开号：
CL2013000545A1
申请日:
2013.02.25
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.ANTICUERPO ANTI-OX40； ACIDO NUCLEICO QUE LO CODIFICA； CELULA HUESPED； METODO DE PRODUCCION； Y USO PARA TRATAR CANCER.
