Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase

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专利权人:

发明人:

Robert Schwarcz,Gabriele Costantino,Laura Amori

申请号：

US14932280

公开号：

US09487486B2

申请日:

2015.11.04

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A derivative of nicotinic acid N-oxide is described having formula (I): that acts as inhibitor of enzyme 3-hydroxyanthranilate-3,4-dioxygenase (3HAO), and is thus able to reduce QUIN biosynthesis in vivo under excitotoxic or pathological conditions, said compound being at the same time also chemically stable towards auto-oxidation.

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