DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE

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专利权人:

UNIVERSITA DEGLI STUDI DI PARMA

发明人:

COSTANTINO, Gabriele,AMORI, Laura,SCHWARCZ, Robert

申请号：

EPEP2011/050670

公开号：

WO2012/097869A1

申请日:

2011.01.19

申请国别(地区):

WO

年份:

2012

代理人:

摘要：

A derivative of nicotinic acid N-oxide is described having formula (I): that acts as inhibitor of enzyme 3-hydroxyanthranilate-3,4-dioxygenase (3HAO), and is thus able to reduce QUIN biosynthesis in vivo under excitotoxic or pathological conditions, said compound being at the same time also chemically stable towards auto-oxidation.Linvention concerne un dérivé du n-oxyde dacide nicotinique répondant à la formule (I) : qui agit en tant quinhibiteur de lenzyme 3-hydroxyanthranilate-3,4-dioxygénase (3HAO) et qui est ainsi capable de réduire la biosynthèse de QUIN in vivo dans des conditions excitotoxiques ou pathologiques, ledit composé étant également en outre chimiquement stable vis-à-vis dune auto-oxydation.

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