Nitrated-fatty acids modulation of type II diabetes

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专利权人:

发明人:

Bruce A. Freeman

申请号：

US13666827

公开号：

US08735449B2

申请日:

2012.11.01

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ.

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