University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Bruce A. Freeman,Francisco J. Schopfer
申请号：
US16748453
公开号：
US20200230095A1
申请日:
2020.01.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ.
