Imidazole compounds that modulate HSP90 activity

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专利权人:

シンタ ファーマシューティカルズ コーポレーション

发明人:

イン ウェイウェン,ドゥ チェンジャン,フォーレイ ケヴィン

申请号：

JP2008527009

公开号：

JP5683787B2

申请日:

2006.08.10

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell Variable R5 is an optionally substituted heteroaryl； an optionally substituted 6 to 14-membered aryl； a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms； or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.

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