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NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF
专利权人:
发明人:
申请号:
EP12732005.9
公开号:
EP2662367A1
申请日:
2012.01.06
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The the present invention relates to provision of a novel indazole compound which is capable of inhibiting HSP90 and shows a cytostatic effect on cancer cells. The present invention also relates to provision of a drug useful for preventing and/or treating, on the basis of an HSP90 inhibitory effect, a disease in which HSP90 participates, in particular, cancer. A compound represented by the general formula (I) or a salt thereof:whereinX represents CH or Nany one or two of Y1, Y2, Y3, and Y4 represent C-R3 or N, and the others represent CHA and B are the same or different and represent an optionally substituted monocyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and OR1 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.R2 represents a hydrogen atom, a halogen atom etc.R3 represents a hydrogen atom, a halogen atom etc.R4 and R5 are the same or different and represent a hydroxyl group etc.R6 and R7 are the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms etc. andR8 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.
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