The present invention relates to a composition for preventing or treating neurodegenerative diseases containing a mixed extract of mate and hwangchil as an active ingredient, and a composition for preventing or treating neurodegenerative diseases containing the mixed extract of mate and hwangchil of the present invention as an active ingredient It was confirmed that when the silver mate extract and the hwangchil extract were mixed, not only showed a synergistic effect on the inhibition of neuroinflammation, but also reduced cytotoxicity. In addition, inhibition of production of inflammatory factors including NO, iNOS and COX-2, inhibition of production of inflammatory cytokines including IL-1β, IL-6 and TNF-α, mitogen-activated protein kinases (MAPK) and NF-κB ( Nuclear factor kappa-light-chain-enhancer of activated B cells) was found to be able to effectively control neuroinflammation by inhibiting the activity, so it can be usefully used in pharmaceutical compositions for the treatment and prevention of neurodegenerative diseases or health functional foods. have.본 발명은 마테 및 황칠 혼합 추출물을 유효성분으로 함유하는 신경변성질환의 예방 또는 치료용 조성물에 관한 것으로, 본 발명의 마테 및 황칠 혼합 추출물을 유효성분으로 함유하는 신경변성질환의 예방 또는 치료용 조성물은 마테 추출물 및 황칠 추출물 혼합 사용시에 신경염증 억제에 대해 상승효과를 보일뿐만 아니라, 세포 독성이 감소한 것을 확인하였다. 또한, NO, iNOS 및 COX-2를 포함하는 염증인자 생성 억제, IL-1β, IL-6 및 TNF-α를 포함하는 염증성 사이토카인 생성 억제, MAPK(mitogen-activated protein kinases) 및 NF-κB(nuclear factor kappa-light-chain-enhancer of activated B cells)의 활성 억제를 통해 효과적으로 신경염증을 조절할 수 있는 것을 확인하였으므로, 신경변성 질환의 치료 및 예방용 약학적 조성물 또는 건강기능성 식품에 유용하게 이용할 수 있다.
