HEBACH, Christina,KALLEN, Joerg,NOZULAK, Joachim,TINTELNOT-BLOMLEY, Marina,WIDLER, Leo
申请号：
ES12805774
公开号：
ES2606630T3
申请日:
2012.11.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (I), or a pharmaceutically acceptable salt thereof, ** Formula ** in which X1 represents N or CR1； X2 represents N or CR2； X3 represents N or CH； X4 represents N or CH； and in which at least one of X1, X2, X3 and X4 is N and no more than two of X1, X2, X3 and X4 are N； R1 and R2 independently represent hydrogen, chlorine or C1-3 alkyl； L1 and L2 independently represent a bond or -C (>； = O) -； R3 represents hydrogen or C1-3 alkyl； n represents 0, 1, 2 or 3； R4 and R5 independently at each occurrence represent hydrogen, fluoro or C1-3 alkyl； R6 represents hydrogen, hydroxy, fluoro, -NR7R8, phenyl or a 5- or 6-membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O and S and wherein said phenyl or heteroaryl is optionally substituted by 1, 2, 3, 4 or 5 substituents, which may be the same or different, selected from R9； R7 and R8 independently represent hydrogen, C1-4 alkyl or benzyl in which the benzene ring is optionally substituted by 1, 2, 3, 4 or 5 substituents, which may be the same or different, selected from R9； and R9 represents cyano, amino, halogen, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, halogen C1-4 alkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 alkylamino, C1- dialkylamino 4, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, aminocarbonyl, C1-4 aminocarbonylalkyl, C1-4 alkylaminocarbonyl, C1-4 dialkylaminocarbonyl or C1-4 alkoxycarbonylamino.Un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo,**Fórmula** en la que X1 representa N o CR1； X2 representa N o CR2； X3 representa N o CH； X4 representa N o CH； y en la que por lo menos uno de X1, X2, X3 y X4 es N y no más de dos de X1, X2, X3 y X4 son N； R1 y R2 independientemente representan hidrógeno, cloro o alquilo C1-3； L1 y L2 independientemente representan un enlace o -C(>；=O)-； R3 representa hidrógeno o alquilo C1-3； n representa 0, 1, 2 o 3； R4 y R5 independientemente en cada ocurrencia representan hidrógeno, fluoro o a
