The present invention provides the methods for treating and improving high cholemia or cholestatic liver disease by apical sodium dependence bile acid transporter inhibitor (ASBTI) from therapeutically effective amount to individuals in need or its pharmaceutically acceptable salt for applying. The present invention also provides hepatopathy is treated and improved with what, reduces the method that serum bile acid or liver bile sour water are quasi-, treat and improve pruritus, reduce liver enzyme or reduce bilirubin, this method includes the ASBTI or its pharmaceutically acceptable salt to individuals in need application therapeutically effective amount.本發明提供了通過向有此需要的個體施用治療有效量的頂端鈉依賴性膽汁酸轉運蛋白抑制劑(ASBTI)或其藥學上可接受的鹽來治療和改善高膽血症或膽汁淤積性肝病的方法。本發明還提供了用於治療和改善肝病、降低血清膽汁酸或肝臟膽汁酸水準、治療和改善瘙癢症、減少肝酶或減少膽紅素的方法，該方法包括向有此需要的個體施用治療有效量的ASBTI或其藥學上可接受的鹽。
