Despite major technological improvements in catheter systems, the indwelling catheter remains the most common cause of nosocomial infection in medical practice. In patients using long-term indwelling catheters, bacterial bio-films can block the various body fluid flows and harbour pathogens that cause various infections in tracts. Bio-films are both tenacious and highly resistant to antimicrobial treatment the conventional method of using antibiotics to prevent the risk of infections due to bio-film, may lead to the development of drug-resistant bacteria. It is necessary to require a modified catheter tube to overcome these problems. Polyethylene glycol (PEG) a polyether compound, used for many applications in manufacturing the medicine, industrial, and clinical product. PEG is used to cause extreme changes in cell morphology within minutes after addition of PEG to the cells. PEG meets many of the physicochemical requirements for an ideal disinfectant for topical use. PEG is neutral, odourless, highly soluble in water (soluble in all proportions), and non-irritating to the skin, does not decay, has a low vapour pressure, and its toxicity from acute oral administration or topical application is low. In this work, the PEG coated catheter tube has been developed to assess its ability to inhibit bio-film formation. Four different human pathogenic microorganisms were used to study the bio-film formation. The effect of PEG coating surface inhibit the bio-film formation on catheter tubes has been analyzed by various instrumental methods. The results of this studies suggested that PEGylated catheter tubes can prevent bio-film formation and associated infections that may occurs within 24 hours of incorporation of catheters.
