Guohua Chen,Paul R. Houston,Lothar W. Kleiner,Jeremy C. Wright
申请号：
US13943719
公开号：
US20140051770A1
申请日:
2013.07.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight； and the polymer matrix has a broad molecular weight distribution of the plurality of polymers； a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith； and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
