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Injectable multimodal polymer depot compositions and uses thereof
专利权人:
Guohua Chen;Lothar Kleiner;Paul Houston;Jeremy Wright
发明人:
Guohua Chen,Paul Houston,Lothar Kleiner,Jeremy Wright
申请号:
US10628984
公开号:
US08501215B2
申请日:
2003.07.28
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
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