The invention provides monovalent, asymmetric tandem Fab bispecific antibodies that can bind two epitopes or two antigens, compositions comprising such antibodies, uses of such antibodies, methods of making such antibodies, nucleic acids encoding such antibodies, and host cells comprising such nucleic acids.本發明提供一種可結合兩個抗原決定基或兩個抗原之單價不對稱串聯Fab雙特異性抗體;包含此類抗體之組合物;此類抗體之用途;製造此類抗體之方法;編碼此類抗體之核酸及包含此類核酸之宿主細胞。