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Chimeric lyssavirus nucleic acids and polypeptides
专利权人:
发明人:
申请号:
EP06112582.9
公开号:
EP1721982B1
申请日:
2000.04.17
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a lyssavirus glycoprotein, which has been found to improve the immunogenicity of lyssavirus epitopes for protection from rabies. The chimeric nucleic acids and proteins can also contain antigenic determinants for epitopes other than those of lyssavirus. Thus, the invention provides chimeric nucleic acids and polypeptides that elicit a strong immune response to multiple antigens. Use of the methods of the present invention permits DNA vaccination without the need to supply multiple antigens on separate DNA molecules.
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