The present invention relates to comprise the nucleic acid molecule of double stranded region, and its nucleic acid construct of coding, they can be used for treating and/or preventing influenza.Especially, the nucleic acid construct of the double stranded rna molecule that the present invention relates to encode, it can be used to produce the transgenosis poultry, chicken for example, thus they are lower to the susceptibility that bird flu is infected at least.The nucleic acid molecule that comprises double stranded region also is provided, and it can treat and/or prevent bird flu in the poultry for example as therapeutical agent.
