The application discloses a device and a related method for receiving blood from the skin and/or from beneath the skin of a subject. The device (10) comprising: a substance transfer component (25) for receiving blood from the skin of the subject； a vacuum chamber regulator comprising a pre-packaged vacuum chamber (35) having an internal pressure less than atmospheric pressure prior to the point at which the device is used on the subject； and a removable module comprising a substrate for absorbing blood received from the subject, wherein the substrate (20, 50) comprises filter paper and/or cotton-based paper, preferably wherein the substrate comprises Whatman 903TM paper.
