UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS
发明人:
ROSS, TED M.,CARTER, DONALD M.,CREVAR, COREY J.
申请号：
HK15104019.2
公开号：
HK1203524A
申请日:
2015.04.24
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H3N2, H2N2 and B influenza isolates. Provided herein are optimized H3N2, H2N2 and B influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
