您的位置: 首页 > 农业专利 > 详情页

計算為H3N2,H2N2,和B流感病毒優化的廣泛反應性抗原
专利权人:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS
发明人:
ROSS, TED M.,CARTER, DONALD M.,CREVAR, COREY J.
申请号:
HK15104019.2
公开号:
HK1203524A
申请日:
2015.04.24
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H3N2, H2N2 and B influenza isolates. Provided herein are optimized H3N2, H2N2 and B influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充